#Health : Suicide in the U.S. has never been higher even as the use of SSRI antidepressants has also never been higher.!

Antidepressant use and the climbing rate of the suicide by Martha Rosenberg .

It is not clear whether Anthony Bourdain and Kate Spade were getting drug treatment for depression. What is clear is that suicide in the U.S. has never been higher even as the use of SSRI antidepressants has also never been higher. One in every eight American adults recently took an antidepressant says the CDC and the number is only rising. Are the drugs working? 

Kate Spade and Anthony Bourdain

The use of antidepressants almost tripled after direct-to-consumer drug advertising began. Only 13.4 million Americans took antidepressants in 1999-2000 ballooning to 34.4 million in 2013-4. In 2015 one in four U.S. women were on psychiatric drugs, usually antidepressants.

Antidepressants were once a short-term therapy to help people get over a troubled time but long-term use has doubled since 2010 and tripled since 2000 so that 15.5 million Americans have been taking the medications for at least five years. “By the mid-1990s, drug makers had convinced government regulators that when taken long-term, the medications sharply reduced the risk of relapse in people with chronic, recurrent depression,” reported the New York Times. 

Yet the jury is still out on the efficacy or safety of antidepressants used long-term. For example, SSRI antidepressant tachyphylaxis can be as high as 33 percent. And studies are only beginning to describe long-term side effects such as the link between SSRI use, BMD deterioration and fractures. In fact, SSRIs may interfere with osteoclast differentiation. 

What is also clear is that some patients feel unable to discontinue SSRI therapy because of side effects and feel “parked” on the drugs. 

Antidepressant Drugs vs Side Effects 

The most popular types of antidepressants are called selective serotonin reuptake inhibitors (SSRIs). These include:
• Fluoxetine (Prozac)
• Citalopram (Celexa)
• Sertraline (Zoloft)
• Paroxetine (Paxil)
• Escitalopram (Lexapro).

Antidepressants are medications commonly used to treat depression. Antidepressants are also used for other health conditions, such as anxiety, pain and insomnia. Although antidepressants are not FDA-approved specifically to treat ADHD, antidepressants are sometimes used to treat ADHD in adults.
The antidepressant drugs used today counteract the effects of neurotransmitter deficiencies in three ways.
I. First, they may inhibit the effects of MAO, leading to increased NE or 5HT in the synaptic cleft.
II. Second, they may block reuptake by the releasing nerve, leading to increased neurotransmitter levels in the synaptic cleft.
III. Third, they may regulate receptor sites and the breakdown of neurotransmitters, leading to an accumulation of neurotransmitter in the synaptic cleft.
Antidepressants may be classified into three groups:

I. the tricyclic antidepressants (TCAs),
II. the MAOIs, and the selective serotonin reuptake inhibitors (SSRIs).
III. Other drugs that are used as antidepressants similarly increase the synaptic cleft concentrations of these neurotransmitters.

In April, the New York Times reported that SSRI antidepressants can be very difficult to quit. In fact, the withdrawal from them––which drug makers call a “discontinuation syndrome” — is similar to that of addictive drugs. Many patients are miffed that they were not warmed by their doctors they may be on the drugs indefinitely said the Times thanks to side effects of dizziness, nausea, headache and brain zaps which do not go away quickly when they try to stop the drugs. Brian, a 29-year-old Chicagoan I interviewed who did not want his name used, told me he has remained on a SSRI antidepressant for years despite his wish to quit. “Every time I try to stop, I get something that feels like an electrical current in my head and I can’t do it,” he says. 

The Times article drew a huge backlash from psychiatrists. “By amplifying the social media echo chamber, the article creates the unfortunate impression that most patients are forced to continue antidepressants out of fear of withdrawal rather than out of prevention of recurrence,” wrote 39 psychiatrists, terming depression “chronic” and “undertreated.” 

Yet, before direct-to-consumer ads, lucrative SSRI antidepressants and doctors paid to promote drugs, “chronic depression” and long-term drug therapy were not the norm. 

Finally, the very definition of depression itself, which is not detectable from lab tests, is expanding. Gone are the days when bad or sad moods are attributed to real problems with finance, romance, debt, jobs, housing, careers, family, marriages, and health. The antidepressant revolution has created an expectation that people who are not “more than happy” all the time need medication. The climbing suicide rate suggests the drugs are not working very well.

Martha Rosenberg is a health reporter and the author of Born With a Junk Food Deficiency.  

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